Coach Peter Moores says the decision to leave opener Stephen Moore out of the side is an attempt to freshen up Lancashire's batting line-up.
Luke Procter has been selected ahead of Moore, who has yet to score a Championship half-century this season, for the game against Worcestershire.
"Stephen's had a very good one-day season, where he's dominated and played some really good cricket," said Moores.
"In the Championship, he just hasn't been able to get the scores."
Speaking to BBC Radio Lancashire, Moores continued: "He's worked very hard and there's no lack of effort on Stephen's part.
"You feel for players when their form goes away and it always seems that things don't go your way.
"I think it was time to freshen things up a bit. Stephen understands the situation and if you're not getting wickets or runs, you're under pressure as a player.
"The player's challenge is to deliver. It doesn't mean we don't like the player, it's just the reality of picking what we think at the time is the best side."
South African-born Moore has managed just 363 runs in 22 Championship innings, averaging less than 17.
Meanwhile, Lancashire's final County Championship game of the season against Surrey, beginning on Tuesday, 11 September, has been switched from Old Trafford to Aigburth.