Former champion Andy Schleck has pulled out of the Tour de France with a knee injury.
"The ligaments and meniscus in the right knee are too severely damaged," said his Trek Factory team.
Schleck tweeted: "Very disappointed to let you know that I will not be able to start. This is a huge blow."
The 29-year-old, who will now travel to Switzerland for further medical tests, crashed in London close to Olympic Park, home of the 2012 Games.