Alberto Contador lost his lead in the Giro d'Italia after a crash caused chaos 3.2km from the finish of stage 13 in Jesolo.
Spaniard Contador was brought down and his 17-second advantage was wiped out, with Italian Fabio Aru taking the lead.
Astana rider Aru, 24, is now 19 seconds ahead of Tinkoff-Saxo's Contador, 32, in the general classification.
Sacha Modolo sprinted to victory ahead of the crash that all but ended the hopes of Team Sky's Richie Porte.
Australian Porte, 30, slipped to 16th in the GC standings after surrendering more than two minutes.
Contador, who had never previously lost a leaders' journey during a Grand Tour, suffered a dislocated shoulder in a crash during stage six.
He told Eurosport he was still suffering with the shoulder injury but was confident he could make the time up on Aru.
Stage 13 result
1 Sacha Modolo (Ita/Lampre-Merida) 3hrs 3mins 8secs
2 Giacomo Nizzolo Giacomo (Ita/Trek Factory Racing) same time
3 Elia Viviani (Ita/Team Sky) st
4 Alexander Porsev (Rus/Team Katush) st
5 Eduard Grosu (Rom/Nippo-Vini Fantini) st
6 Ariel Richeze (Arg/Lampre-Merida) st
7 Moreno Hofland (Ned/Team LottoNL-Jumbo) st
8 Nicola Ruffoni (Ita/Bardiani-CSF Pro Team) st
9 Luka Mezgec (Slo/Giant-Alpecin) st
10 Henrich Haussler (Aus/IAM Cycling) st
General classification after stage 13
1 Fabio Aru (Ita/Astana) 54hrs 20mins 35secs
2 Alberto Contador (Esp/Tinkoff-Saxo) +19secs
3 Mikel Landa (Esp/Astana) +1min 14secs
4 Roman Kreuziger (Cze/Tinkoff-Saxo) +1min 38secs
5 Dario Cataldo (Ita/Astana) +1min 49secs