GB men's wheelchair basketball captain Jon Pollock will miss September's European Championships in Israel after failing to overcome a shoulder injury.
The absence of the experienced Pollock, who has played at three Paralympics, will be a blow to Britain's hopes of success.
He will be replaced by 16-year-old Harry Brown, who made his senior debut in May's Paralympic World Cup.
The competition takes place in Nazareth from 8-17 September.
The team finished third at the Paralympic World Cup in Manchester, losing to France and Canada before beating Brazil.
Ahead of the Europeans they will attend the Spitfire Tournament in Ontario, Canada and the USA Invitational in Charlotte, North Carolina before facing the hosts Israel, Italy, Turkey, Switzerland and Belgium in the pool stages.
Much will depend on the performances of the likes of Simon Munn, Terry Bywater and Abdi Jama as GB chase a first European title since 1995.
Head Coach Murray Treseder said: "We have chosen the strongest squad we can. We will sorely miss Jon Pollock's leadership and experience but this will allow us to play a number of different rotations and combinations and allow emerging players to come through and stamp their mark in the team."
"The European Championships is full of very strong teams and it is anyone's for the taking.
"We expect that our preparation prior to the tournament will give us the best chance of going and being able to perform at the highest level we possibly can."
GB squad: Abdi Jama, Matt Byrne, Jon Hall, Dan Highcock (Rhinos), Peter Finbow, Ian Sagar (Owls), Matt Sealy, Ade Orogbemi, Simon Munn, Gaz Choudhry (Capital City), Harry Brown, Terry Bywater (Steelers)