London 2012 champions Mark Colbourne and David Stone led the way with a gold and a silver medal apiece at the Para-Cycling Road World Cup in Italy.
Colbourne had a maiden C1 road race victory over Germany's Michael Teuber in the first major competition since last year's Paralympics.
Stone, who races on a trike, beat Hans-Peter Durst in the T2 time trial before the German took road-race revenge.
Great Britain's Lora Turnham and Fiona Duncan won tandem time trial silver.
Team-mate Crystal Lane won bronze in both the C5 time trial and road race.
Colbourne had finished 58 seconds behind Teuber in Friday's time trial but found Saturday's road race course in Merano, two hours north of Verona, more to his liking.
The 43-year-old, who won a gold and two silvers in London, relished the technical course and won in a sprint finish at the end of the 10-lap circuit for his first major international road race win.
Turnham and Duncan put in a strong finish in their time trial, but finished nine seconds behind the strong Canadian pairing of Robbi Weldon and Emilie Roy.
They failed to add to their medal haul in Sunday's road race where they suffered a crash, but both will be fit for next weekend's Road World Cup in Segovia, Spain.
"We had a mixed bag of results but we are pleased with the medal haul," British Cycling Paralympic performance director Gareth Sheppard told BBC Sport.
"Some of the guys will be looking to step up in Spain and the challenges they faced here will put them in good stead for next week and also for selection for the World Championships in August in Canada."