Britain's Jonnie Peacock, the T44 100m world champion, has been ruled out of the IPC Athletics World Championships in Qatar.
Peacock, 22, will miss the rest of the season with a sore on his leg.
Six of the 48-strong British team will defend titles, including Hannah Cockroft in the T34 100m and 200m, and Richard Whitehead in the T42 200m.
Wheelchair racer Kare Adenegan, 14, will be the youngest member of the squad in Doha between October 22-31.
Paralympic champion Peacock said: "These decisions are never easy but I have to think of the long term effects and give it the rest it needs.
"It will be tough being on the sidelines but I'm sure it will be a great event and I'll be cheering on the team from the UK."
Sophie Hahn (T38 100m and 200m), Hollie Arnold (F46 javelin) and Paul Blake (T36 800M) will also defend their titles won in Lyon, France two years ago.
Six-time Paralympic, world and London Marathon winner David Weir will compete for the first time since winning four gold medals at London 2012.
However, 800m T54 European silver medallist Jade Jones misses out with a wrist injury.
|Analysis - Ed Harry, Paralympic commentator|
|The night Jonnie Peacock won Paralympic gold in London was the Paralympics' equivalent of 'Super Saturday'. A teenager, lining up against Oscar Pistorius, it was Peacock who hushed the crowd so the race could start.|
|In less than 11 seconds, British athletics had a new star. Peacock beat Richard Browne to gold, and did so again at the 2013 worlds.|
|But the American is quicker, and - like two boxers - they've built a rivalry that transcends their event. It's exactly what Paralympic sport needs and, without Peacock in Doha, that star quality will be missed.|