Sheffield Wednesday picked up their first back-to-back home wins in five months as Tranmere were swept aside.
Tommy Miller opened the scoring from Neil Mellor's nod down following a Gary Teale cross from the right.
Gary Medine made it 2-0 when he latched onto Mellor's through ball and slotted past keeper Tony Warner.
Miller doubled his tally from the spot after Mellor was fouled in the box by Michael Kay before Mellor squeezed in Clinton Morrison's flick-on.
Sheffield Wednesday midfielder Tommy Miller told BBC Radio Sheffield:
"Delighted. After Saturday's win, it was important to follow it up with another. Great three points and a convincing win.
"This season at home we've underachieved, we've been disappointing. Saturday's win gave us a bit of confidence and we blew them away with the goals in the first half.
"It's just nice to stay fit and get a run in the team. Hopefully I can stay in the team till the end of the season"
Tranmere manager Les Parry told BBC Radio Merseyside:
"We knew Sheffield Wednesday were just going to turn us all the time, and they did.
"For some unknown reason we tried to pass it in triangles, which you can't do and we come unstuck.
"We missed Ian Goodison and Andy Robinson, who are two quality players. We have other quality players, but they give us something different."