Portadown midfielders Alan Cawley and David McCullough will leave the club after Saturday's final Premiership game against champions Linfield at Windsor Park.
Cawley departs less than three months after joining the Ports.
Portadown striker Matthew Tipton returns from suspension to face the Blues, who will be presented with the Gibson Cup after the game.
Crusaders have Aidan Watson back from a ban for the visit to Glentoran.
It is expected that the Crues and Linfield will rest a number of players ahead of the Irish Cup final next Saturday.
Meanwhile, Carrick Rangers will confirm their promotion to the Premiership if they beat Banbridge Town on Saturday.
Limavady United, who have three games remaining, trail the Championship leaders by seven points.
Saturday 30 April - 1500 BST kick-off
Linfield v Portadown
Glentoran v Crusaders
Newry City v Coleraine
Ballymena Utd v Glenavon
Donegal Celtic v Dungannon Swifts