Sunderland are set to be without midfielders Kieran Richardson and Lee Cattermole as well as defender Michael Turner for the final three games of the season.
Richardson, 26, has a stress fracture in his left leg, Cattermole, 23, has a back injury and Turner, 28, is suffering from a knee problem.
"We've got about 11 players injured and 10 of them probably won't play again this season," said Black Cats boss Steve Bruce.
"We've just got to get on with it."
The trio are likely to miss Premier League matches against Bolton, Wolves and West Ham, with Sunderland six points above the top-flight drop zone.
Richardson's last outing came when he was substituted in the 3-2 defeat by West Brom and he has since been sidelined for three games.
"We X-rayed him after the game against West Brom and then subsequently scanned him two or three days later," explained Bruce.
"The scans and the X-rays revealed nothing at all apart from a badly bruised bone.
"Unfortunately, what the medical people are telling me is that they [stress fractures] can appear within 10 days to three weeks.
"Consequently, we re-scanned him on Thursday when we detected that unfortunately, the boy has got a stress fracture and will miss the rest of the season."
"But we hope he [Richardson] is going to be joining in pre-season."