Club captain Richard Naylor will leave Leeds United when his contract expires in June.
The 34-year-old made 76 appearances for the club and captained Leeds to promotion from League One in 2009/10.
The Yorkshire club have released loan signings Sanchez Watt (Arsenal), Jake Livermore (Tottenham), George McCartney and David Gonzalez (Manchester City).
Goalkeeper Shane Higgs is to exit, but Honduran Ramon Nunez has signed a six-month deal after a spell at Scunthorpe.
Defender Naylor was manager Simon Grayson's first signing as Leeds boss when he initially joined on loan from Ipswich in January 2009.
He has featured 15 times for the club in the Championship this season.
Grayson told Leeds' official website: "I'd like to thank Richard for everything he has done during his two and a half years with us.
"He's been a great captain for the club, both on and off the field and I can't speak highly enough of him and what he's done.
"Unfortunately we're not in a position where I can offer him regular football now and allowing him to move on will give him the best possible opportunity elsewhere."
Leeds were narrowly beaten to a play-off place after being overtaken by Nottingham Forest in the closing stages of the season.
But they rounded off their campaign with a 2-1 win against champions QPR at Loftus Road on Saturday.
Grayson continued: "I'd like to thank all the loan players who have come at different stages.
"Sanchez has obviously been with us for the full year and the end of last season, but each and every one of them has played a part in what we have done over the past 12 months."
And of 25-year-old Nunez, Grayson added: "He's a talented player and he's proved that by doing well at Scunthorpe. He will come back in the summer with an opportunity to make an impression here."