An injury-time goal from Uruguay denied Rwanda their first ever point at a global football event as they lost 1-0 at the Under-17 World Cup on Wednesday.
Despite the loss Rwanda still have a mathematical chance of reaching the last 16 if they can win their final Group C game with Canada on 25 June.
The only goal of the game in Mexico came five minutes into injury time as Uruguay goalkeeper Jonathan Cubero's hopeful free-kick up field found Leonardo Pais, who headed home.
Rwanda started the game well and had much of the play in the midfield early on, coming close to scoring with two free-kicks from captain Emery Bayisenge.
The first hit the post, with Cubero beaten, and the second curled over the crossbar.
The Baby Wasps' rhythm was interrupted when coach Richard Tardy was forced to make early substitution, when a knee injury forced defender Faustin Usengimana to leave the pitch.
The South Americans took advantage of the switch to become more attacking, if only through the occasional counter-attack.
Rwanda managed two good shots in the closing minutes of the half but failed to convert either.
Uruguay dominated the second half and Gaston Silva, Juan Cruz Mascia, substitute Heber Ratti and Elbio Alvarez all had good chances to break the deadlock.
The win means Uruguay are through to the last 16 and next up for them is a game on 25 June against England, who were held to a 2-2 draw by Canada in Wednesday's other Group C encounter.