Bob Bradley has been sacked as United States coach after four and a half years in charge.
The 53-year-old took the team to the last 16 of the 2010 World Cup after drawing 1-1 with England in Group C.
Bradley was subsequently linked with the Aston Villa manager's job, before opting to sign a four-year deal extension with US Soccer.
"We felt now was the right time for us to make a change," said US Soccer president Sunil Gulati.
Bradley's departure follows a 4-2 defeat by Mexico in the Gold Cup final on 25 June.
But his reign also included a shock win over European champions Spain en route to a runners-up finish at the 2009 Confederations Cup and last summer's creditable World Cup campaign that ended in extra-time defeat by Ghana.
"It is always hard to make these decisions, especially when it involves someone we respect as much as Bob," added Gulati.
"We wish him the best in his future endeavours."
US Soccer added that it would make a further announcement on Friday, raising expectations that it may name a replacement.