Preston 2-4 Colchester
Colchester's Ian Henderson scored twice to help his side beat Preston.
The U's led when Anthony Wordsworth fired home a fierce effort in the bottom corner and he then set up Henderson to net from 12 yards.
North End replied through Neil Mellor's clinical shot but Henderson made it 3-1 from 20 yards out.
Preston again responded thanks to Paul Coutts' strike from range but Kayode Odejayi scored from six yards to seal the victory.
VIEWS FROM THE DRESSING ROOM
Colchester United manager John Ward told BBC Essex:
"We've beaten a very good team. I don't think very many will score four or win here.
"A major problem last year was scoring goals away from home.
"The finishing was a lot better, we've worked very hard at it."