Ex-Norway U21 goalkeeper Adam Kwarasey is among three players handed their debut call-ups by Ghana.
England-born winger Albert Adomah was named in coach Goran Stevanovic's squad for the 9 August friendly against Nigeria in London.
Former U21 midfielder Rabiu Mohammed also got his first call-up to replace the injured Michael Essien.
The trio are among a host of players given the chance to press their claims for permanent places in the team.
Midfielder Prince Buaben returns to the fold after a two-year absence while Kevin Prince Boateng has been excused from international duty.
Kwarasey, who was born in Norway to a Ghanaian father and Danish mother, opted to play for the Black Stars three years ago.
But his nationality switch was only cleared recently which paved the way for him to be named to challenge Richard Kingson as the country's first choice shot-stopper.
Adomah, whose parents are from the West African country, has been invited for the first time after impressing with English Championship Bristol City.
"My mum and dad and most of my family are from Ghana, so this feels like the right thing to do," Adomah said recently.
"I was born and raised in this country, but I have very close ties with Ghana and this is not just me using a loophole to play international football.
"For me, it's not a matter of choosing Ghana over England. I have dual nationality and passports for both countries.
"In the end, it was not a difficult decision to make."
The Black Stars will play their arch-rivals Nigeria at Watford's Vicarage Road.
The game will be the second meeting between the two sides in England.
Ghana thumped Nigeria 4-1 in their first meeting in England four years ago.
Goalkeepers: Richard Kingson (Unattached), Adam Larsen Kwarasey (Stromgodest)
Defenders: Samuel Inkoom (FC Dnipro), John Paintsil (Leicester City), Daniel Opare (Standard Liege), John Mensah (Olympique Lyon), Isaac Vorsah (TSG Hoffenheim), Jonathan Mensah (Evian Thonon-Gaillard)
Midfielders: Anthony Annan (Schalke 04), Prince Buaben (Watford), Andre Ayew (Olympique Marseille), Kwadwo Asamoah, Emmanuel Agyeman-Badu (Udinese), Sulley Muntari (Inter Milan) Rabiu Mohammed (Evian Thonon-Gaillard) Albert Adomah (Bristol City)
Strikers: Asamoah Gyan (Sunderland), Prince Tagoe (TSG Hoffenheim), Dominic Adiyiah (Karsiyaka).