Coleraine pair Kyle McVey and Michael Hegarty will miss the start of the new season, which starts on Saturday.
McVey has broken a foot bone for the second time this year and faces a lengthy lay-off.
"It's disappointing for Kyle after how hard he's worked on his fitness after missing much of the second half of last season," said manager Oran Kearney.
Midfielder Hegarty is out for two weeks after picking up a knee injury in a recent friendly with Ballymoney United.
McVey's first bone break, in the same foot, came in February and resulted in the defender missing the rest of the campaign.