A stunning David Buchanan strike earned Tranmere Rovers victory and left Leyton Orient still looking for their first point of the season.
Defender Buchanan seized possession following a clearance and drilled a 30-yard shot past startled keeper Lee Butcher to settle a dull match.
The visitors' best opportunities saw Jimmy Smith header tamely at Owain Fon Williams and Alex Revell volley wide.
The chances continued to be limited after the break until Buchanan's shot.
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Leyton Orient manager Russell Slade told BBC London 94.9:
"Sometimes it's difficult to put your finger on why you've not won a football match or you've not got something out of a game.
"We've not scored in our first two games of the season and it makes life a lot easier if you can get a goal.
"Today we conceded one off the back of the best spell of the game for us."
Tranmere Rovers manager Les Parry told BBC Radio Merseyside:
"The lads defended well before the end, but we were quite comfortable to be honest.
"There were limited chances during the game and especially in the first half I thought both sides looked comfortable.
"We knew David Buchanan struck a great ball, but that goal was same he scored at home in a friendly and he's a great lad."