Swansea City secured their first point in the Premier League but needed a superb second-half penalty save from Michel Vorm to deny Wigan victory.
New-signing Vorm kept out Ben Watson's low spot kick after Jordi Gomez fell under Ashley Williams' rash challenge.
Moments earlier, Victor Moses and Gomez had struck the Swansea woodwork within seconds of each other.
Swansea dominated possession but their best chance fell in the opening two minutes when Danny Graham was denied.
Manager Brendan Rodgers will be disappointed the home side failed to create more scoring opportunities, but a possible victory could easily have turned into a defeat as Wigan wasted a golden opportunity to snatch an unlikely win.
A conservative Wigan had seemed content to soak up the home pressure, but Roberto Martinez will be cursing his luck and searching for answers having seen his side pick up just a point from a newly promoted team for the second successive match.
All the pre-match talk had focused on Martinez's return to Swansea for the first time since leaving the club to join Wigan in 2009.
The Spaniard laid the foundations on which Rodgers has moulded the Swans into a Premier League side, and it was perhaps appropriate for Martinez to be in the visitors' dug-out for the first top-flight game to be staged in Wales.
A festival atmosphere awaited the players, and the home fans were almost rewarded with a goal from Swansea's first attack.
A typically slick, one-touch build-up freed Angel Rangel down the right flank and record-signing Graham should have done better than to fire straight at Latics keeper Ali Al Habsi.
Swansea proceeded to completely dominate the next 20 minutes, belying their billing as Premier League newcomers, as Graham and Scott Sinclair saw efforts go wide.
Antolin Alcatraz, the only change to Wigan's line-up from the opening day draw with Norwich City, was then at full stretch to deny Graham a simple tap in from Wayne Routledge's low cross as Swansea increased the pressure at the end of the half.
Former Swansea midfielder Gomez recorded Wigan's first shot on goal moments before the break, but the visitors were lucky to escape early in the second half as both Sinclair and Graham failed to make meaningful contact following a goal-mouth scramble.
Swansea continued to probe the Wigan defence with their intricate passing, Routledge firing a shot inches wide.
Having weathered the home pressure, Wigan suddenly found their attacking instincts as Gomez's delightfully controlled effort sailed over Vorm's head but rebounded off the post.
Seconds later, Moses suffered the same fate as his drive crashed against the bar, before a wild challenge by Swansea captain Williams on Gomez resulted in a clear penalty.
Having scored against Norwich last weekend, Watson again went low and left with his spot kick, by Vorm had obviously done his homework and saved at full stretch.
Stephen Dobbie added some late impetus for Swansea when he came off the bench, testing Al Habsi with two long-range efforts.
But Wigan came within inches to snatching victory in the final stages when substitute Maynor Figueroa's front-post flick flashed across the face of goal.
Swansea manager Brendan Rodgers:
"From my side a point was the very least that we deserved, we controlled large parts of the game and created chances which was great to see, and we were just waiting for one of them to go in.
"But you understand that against an established Premier League side you are going to have a five to 10 minute spell, and in that spell they hit the post, hit the bar and got the penalty.
"But I was very proud of the team today, especially early on. It's about results of course, but for us it is always about performance.
"We grew again today from the Manchester City performance, showed great qualities with the ball and we penetrated in behind and created chances. But at this level you need to put them away, which was our downfall today."
Wigan manager Roberto Martinez:
"When you miss a penalty and hit a post and the crossbar you think you should win. If you played that game 10 times you would win it more times than you would draw it.
"We knew the team of Swansea, they were great to see and they used the ball in the great way they do. But we opened up a bit in the second half and we thought we looked a threat every time we went forward.
"You don't get many games where you miss a penalty, hit the post and hit the bar so in that respect I think we dropped two points."