Harrison Dunk scored on his home debut as Cambridge defeated Blue Square Bet Premier newcomers AFC Telford.
The U's grabbed the only goal of the game when Adam Marriott's shot hit the bar and Dunk slammed in the rebound.
Telford, who won promotion from the Blue Square Bet North last season, had an early chance but home goalkeeper Danny Naisbitt twice denied Jon Adams.
Andy Brown had a late chance to grab an equaliser for the visitors but he powered a header over the crossbar.
Cambridge Utd: Naisbitt, Roberts, Coulson, Wylde, Kinniburgh, Carew, Shaw, Berry, Dunk, Charles (Gash 78), Marriott (Jarvis 78). Subs Not Used: Brown, Platt, Thorpe.
Booked: Berry, Carew.
Goals: Dunk 50.
AFC Telford: Young, Valentine, Preston, Killock, Newton, Adams (Samuels 68), Trainer, Davies (Rooney 89), Reid, Brown, Meechan (Farrell 66). Subs Not Used: Lee Evans, Salmon.
Booked: Killock, Davies.
Ref: Robert Whitton (England).