Will Antwi's late equaliser extended Luton's unbeaten start to the season as Mansfield's winless run continued.
Matt Green, on loan from Oxford, curled an effort from 20 yards into the top corner for his first Mansfield goal.
Ben Futcher had a chance to double the lead for The Stags, who have now not won in four games, but he headed wide when unmarked from only five yards out.
That miss proved to be costly as Jake Howells' free-kick was met by Antwi, whose header went in off the post.
Mansfield: Marriott, Kendrick, Riley, Futcher, O'Neill, Meikle, Howell, Murray, Briscoe, Dyer, Green. Subs Not Used: Redmond, Worthington, Stevenson, Connor, Wood.
Booked: Green, Kendrick, Briscoe, Dyer.
Goals: Green 26.
Luton: Tyler, Osano, Beckwith, Antwi, Asafu-Adjaye (Gleeson 56), Howells, Watkins, Dance, Morgan-Smith, Crow, O'Connor (Walker 61). Subs Not Used: K Pilkington, Barnes-Homer, Poku.
Goals: Antwi 78.
Referee: Seb Stockbridge (Tyne & Wear).