Devon rivals Exeter City and Plymouth Argyle meet for the fourth time in a year in the Johnstone's Paint Trophy on Tuesday night.
The clubs are in very different positions, with Exeter coming off a Carling Cup tie with Liverpool.
Meanwhile Argyle are bottom of the Football League and are still in administration despite getting approval for a takeover.
"I can't wait for Tuesday night," City boss Paul Tisdale told BBC Radio Devon.
"We've got no fresh injuries and it's the first time for quite a few weeks where I haven't got to contend with decisions made on people missing," Tisdale added.
Things could not be much different for Argyle.
They are yet to win a game this season and have only scored two goals since the start of the campaign.
But Argyle manager Peter Reid says that could all change with a good showing at St James Park.
"If we get a result it might be the result that changes our season," he said.
"We need to try and get a win under our belts, a goal and try to keep a clean sheet and there's no better game than a derby game to get them in," he added.
"It's a game that I'm certainly looking forward to and hopefully the players are as well," he said.