A magnificent strike from Ed Upson was enough to give Yeovil three points against Wycombe.
Upson's 30-yard strike flew past goalkeeper Nikki Bull, who got a hand to the unstoppable shot.
The midfielder almost grabbed a second but his close-range effort was scrambled off the line by Danny Foster.
Wycombe's best chance of an equaliser was Elliot Benyon's header from inside the area, which was brilliantly saved by Jed Steer.
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Yeovil Town manager Terry Skiverton told BBC Points West:
"I think we were a little bit nervy towards the end of the game - that was down to Wycombe's good play.
"They created us one or two problems and we rode our luck a bit.
"But it was a really professional performance and it's one we can take great heart from as we've kept a clean sheet at home and I think Ed Upson's goal was fit to win any game."
Wycombe Wanderers manager Gary Waddock told BBC Three Counties Radio:
"We're frustrated, we have to move forward and we have to start winning football matches and picking points up, it's as simple as that.
"We're creating stuff, but we're not taking those chances. We're not ruthless enough, we haven't got that cutting edge or that finish at hat the minute.
"But we've got players in the building who can do that."