County Antrim Shield holders Glentoran take on Carrick Rangers on Wednesday knowing they need to reverse their disastrous home record.
Scott Young's men have taken just one point from their last three league games at the Oval and have slid to sixth in the Premiership table.
They will be without striker Andrew Waterworth who is suspended after being sent-off against Cliftonville.
Carrick have added to their panel by signing George Stewart and John Boyce.
Midfielder Boyce is a brother of Northern Ireland international Liam while Stewart signed from Distillery.
Crusaders, Shield winners in 2009-10, take on Lisburn Distillery at Seaview.
Whites manager Tommy Wright is planning some changes, with Saturday's bottom two clash with Glenavon on his mind.
"We will change things around and give an opportunity to players who have been on the bench the last few weeks," said Wright.
"We want to progress in this competition but we have to keep one eye on Saturday."
Ballymena United host Linfield for the second time in five days, the Premiership champions having won 2-1 there last Saturday.
Donegal Celtic, sitting fourth in the league table, play Cliftonville in Wednesday's other quarter-final.
Paddy Power County Antrim Shield - 7 September
Ballymena United v Linfield
Crusaders v Lisburn Distillery
Donegal Celtic v Cliftonville
Glentoran v Carrick Rangers