Two Jamie Vardy goals condemned Gateshead to their first league defeat of the season.
Andy Mangan opened the scoring for Fleetwood, rifling home a thunderous strike from long distance.
The home side got their second on the counter attack, Vardy slotting in Richard Brodie's cross.
Yemi Odubade's free-kick pulled one back for the Heed, but Brodie once against set up Vardy for the striker to net his second.
Fleetwood Town: Davies,Beeley,Atkinson,Linwood,Edwards,Vardy, McGuire,Milligan (Briggs 88),Cox (Mangan 31),Vieira, Seddon (Brodie 73).
Subs Not Used: St Louis-Hamilton,Goodall.
Goals: Mangan 51,Vardy 79,90.
Gateshead: Farman,Odhiambo,Clark,Curtis,Rents, Cummins (Fisher 76),Gate,Turnbull,Odubade,Mulligan, Moore (Gillies 60).
Subs Not Used: Alnwick,Baxter,Carruthers.
Goals: Odubade 90.
Ref: Wayne Barratt (Worcestershire).