Six-time champions Al Ahly crashed out of the African Champions League on Friday after they were held to a 1-1 draw at home by Esperance of Tunisia in a final Group B match.
With that result Ahly could only manage a maximum of seven points to finish third in the group, while Esperance finished top having recorded 10 points.
Ahly's elimination was also sealed after Morocco's Wydad Casablanca were beaten 3-1 by Mouloudia Alger of Algeria in the other group game.
Wydad finished with seven points but qualified ahead of the Egyptian champions by virtue of a better goals difference.
Ahly needed to win by two clear goals to progress into the semifinals, but those hopes were cut short in the 17 minute when Yaya Banana headed home a lead for Esperance.
Egypt International Mohamed Aboutrika equalised for Ahly nine minutes after half time.
Several chances were squandered in the second half, with a last minute attempt by striker Dominique da Silva cleared off the goal line.
In Algeria, hosts Mouloudia Alger shocked Wydad Casablanca with a 3-1 defeat.
Two goals by Mohamed Babouche and a third by Herve Oussale in the second half had given Mouloudia a 3-1 lead up to 79th minute when the Moroccans pulled one back through a penalty converted by skipper Ahmed Ajeddou.
But the result did not mean much for the Algerians who finished bottom of the group with five points.
The Moroccan side qualify for the last four despite originally being knocked out of the tournament in the third round by reigning champions TP Mazembe of DR Congo.
Mazembe were subsequently disqualified from the Champions League for fielding an ineligible player in an earlier round in their win over Simba of Tanzania.
Wydad then beat Simba 3-0 in a one-match play-off in Cairo to detemine who went into the group stages of the tournament.