Worcester City slipped to their second straight 4-1 away defeat in the Blue Square Bet North as Guiseley were comfortable winners at Nethermoor.
Gavin Rothery gave Guiseley a 1-0 lead at the breakand then doubled the advantage two minutes after half-time.
Simon Baldrynetted a third for the home side before Martyn Naylor pulled a goal back for Worcester.
But Guiseley rounded off their win when substitute Alex Davidson scored their fourth a minute from time.
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Worcester manager Carl Heeley told BBC Hereford & Worcester:
"The only way that these situations turn is that we stick together and keep working hard.
"We have to keep believing in each other because there is a lot of ability in there.
"It has not happened again for us today and I know it sounds silly but on another day you would get something as things would go your way a little bit more."