Ballyclare Comrades host giants Linfield on Tuesday night as the minnows take on the mighty in the first round of the Irn-Bru League Cup.
The 12 Premiership sides face junior opposition, including the Dixon Park encounter between Championship Two leaders Ballyclare and the Blues.
Holders Lisburn Distillery start their defence against Tobermore United while Glentoran welcome Killymoon Rangers.
Premiership pacesetters Portadown play Warrenpoint Town at Shamrock Park.
Ports midfielder Shane McCabe is suspended after his red-card in Saturday's 2-0 victory over Linfield.
Bans also rule out Glentoran's Jamie McGovern and Declan Caddell of Crusaders, who are home to PSNI.
There are 15 games on Tuesday night while Carrick Rangers entertain Sport & Leisure Swifts on Wednesday.
There will be live score updates from all 16 games on Ceefax page 390 and the BBC Sport NI website.
Irn-Bru League Cup first round (1945 BST kick-offs)
Tuesday 20 September
Ballyclare Comrades v Linfield
Ballymena Utd v Chimney Corner
Bangor v Annagh Utd
Cliftonville v Ards
Coleraine v Knockbreda
Crusaders v PSNI
Dergview v H&W Welders
Donegal Celtic v Wakehurst
Dungannon Swifts v Loughgall
Glenavon v Coagh Utd
Glentoran v Killymoon Rangers
Lisburn Distillery v Tobermore Utd
Newry City v Larne
Portadown v Warrenpoint Town
Ballinamallard Utd v Limavady Utd (2000)
Wednesday 21 September
Carrick Rangers v Sport & Leisure Swifts