Third-placed Donegal Celtic will be without veteran front man Paul McVeigh as they attempt to continue their best start to a Premiership season.
McVeigh is starting a two-match suspension and misses Saturday's trip to the Coleraine Showgrounds.
DC midfielder Niall Atkinson also has to serve a two-game ban arising from his recent red card against Dungannon.
Celtic and leaders Linfield have the best away record in the Premiership, winning four of their five matches.
Coleraine's run of three league wins in a row ended last week then they lost at bottom club Glenavon.
Cliftonville's unbeaten away record will be put to the test when they play Linfield at Windsor Park.
Tommy Breslin's Reds will have to make do with winger Martin Donnelly because of suspension.
Portadown, level on points with Linfield at the top of the table, will be expected to beat second-from-bottom Carrick Rangers having seen off Glentoran, Linfield and Crusaders in their last three games.
Crusaders, with just one win from six games and minus the banned Chris Morrow, aim to end Lisburn Distillery's league revival at New Grosvenor.
Two wins and two draws from their last four fixtures have seen Tommy Wright's men edge away from the bottom of the table.
Bottom-placed Glenavon, boosted by ther first win of the season last weekend, are at home to Glentoran who have managed just one league win from their last five.
Ballymena will be hopng to get their first home win of the season when they face Dungannon Swifts at the Warden Street Showgrounds.