Newport County manager Justin Edinburgh got off to a losing start at Spytty Park with defeat by Southport.
The visitors took the lead when Simon Grand headed home from close range after Newport defender Paul Rodgers hooked off his own line.
Southport doubled their lead when Karl Ledsham headed in Tony Gray's pinpoint cross past Glyn Thompson.
Gray tapped in the third from Andy Owens' centre as Southport made it three wins in a row.
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Newport County manager Justin Edinburgh told BBC Radio Wales:
"I think we possibly couldn't have got off to a worse start, certainly in the first half.
"We're quite aware of the job ahead now, certainly the players are.
"We've got to understand that it's not going to be pretty at times but we've got to roll up our sleeves now because we're certainly in a dog-fight.
"If I can take some positives out of the second half, a clean sheet and at least we gave it a go and didn't lay down and die, but there's certainly a lot of hard work ahead of us, that's for sure."