Rory Patterson and Curtis Allen will come up against their former sides when Coleraine entertain leaders Linfield at Ballycastle Road on Saturday.
Patterson, now with the Blues, scored goals galore during a one-year stint with the Bannsiders, while Allen left the champions for Coleraine in May.
Leon Knight should return for Coleraine after overcoming a bout of flu but Darren McCauley is ruled out by injury.
David Armstrong, Jamie Mulgrew and Peter Thompson are out for the Blues.
Coleraine manager Oran Kearney must again plan without long-term injury victims Michael Hegarty and Kyle McVey.
Allen has scored four goals in 10 Premiership games to date.
Brothers Stephen and Philip Lowry will also find themselves on opposing sides at the Showgrounds.
Portadown are level on points with David Jeffrey's side at the top of the table, and they travel to face a Ballymena United side who are still looking for their first home win.
Ports manager Ronnie McFall has been named as Carling Football Writers' Manager of the Month for September, the second month in succession that he has claimed the award.
Cliftonville are still without the suspended Martin Donnelly for their home game against Dungannon Swifts.
Chris Morrow is also banned for Crusaders' home game against basement side Glenavon.
Paul McVeigh and Niall Atkinson will sit out Donegal Celtic's game with Carrick Rangers at Suffolk Road.
Lisburn Distillery play Glentoran at New Grosvenor in the day's other game.
Saturday 8 October - Carling Premiership - 1500 BST
Ballymena Utd v Portadown
Cliftonville v Dungannon Swifts
Coleraine v Linfield
Crusaders v Glenavon
Donegal Celtic v Carrick Rangers
Lisburn Distillery v Glentoran