Fabio Capello could call on John Terry for England's friendly with Spain after Phil Jagielka suffered a hairline fracture of his toe.
Terry - the subject of police and FA investigations over an alleged racist remark - was expected to be left out.
But Capello, who will miss his son's wedding to take charge on Saturday, is left with limited options.
Joleon Lescott, Gary Cahill and Phil Jones are the other centre-backs in the squad.
Bolton defender Cahill and Manchester City's Lescott remain in pole position to start as the Italian seeks to test out alternative options for Euro 2012.
It gives the England manager a selection dilemma after he earlier indicated his captain was likely to be left out following a difficult period for the Chelsea player.
Jagielka's condition will be assessed in the next 24 hours by the England medical staff.
Meanwhile, the Football Association has confirmed that Capello will miss his son's wedding in Milan because of a clash with the friendly against the world and European champions at Wembley.
The match was originally scheduled for Friday evening but had to be moved back 24 hours because Barcelona, who provide eight players to the Spanish squad, are in action on Wednesday night against L'Hospitalet in the Copa del Rey.
England host another international friendly against Sweden on Tuesday and Capello has no plans to return to Italy in between the two games.