Glentoran are set to be without four players for the Carling Premiership game against strugglers Glenavon.
Jason Hill, Andy Waterworth and Ciaran Martyn picked up injuries in the Irn-Bru Cup defeat to Coleraine.
Gary Hamilton remains out with a toe problem while Glenavon forward Mark Miskimmin returns from a ban.
"It will be a tough game - Glenavon are fighting for their lives while we have to bounce back and try to get the win," said Glens boss Scott Young.
Leaders Linfield also have injury problems with Rory Patterson and Gary Browne are sidelined for the trip to Donegal Celtic.
Mark McAllister (shin) and Jamie Mulgrew (shoulder) are doubts for the game against a DC side missing the suspended Johnny Harkness.
Cliftonville are boosted by Ryan Catney's return from suspension ahead of the Showgrounds match with Ballymena United, while Sky Blues defender Davy Munster is banned.
Portadown, who are just two points off top spot, will take on Dungannon Swifts at Stangmore Park without striker Matthew Tipton (broken collarbone) and midfielder Sean Mackle (hamstring).
Stefan Lavery (neck) is out for the Swifts although boss Dixie Robinson has Adam McMinn back in the squad.
Crusaders manager Stephen Baxter has a full squad to select from as the north Belfast side prepares for the Seaview meeting with Lisburn Distillery.
The Whites have lost their last seven games but Baxter believes they will be no pushovers with new manager John Cunningham at the helm along with assistant Glenn Ferguson.
"Distillery have beaten us too many times here to take them lightly," said Baxter.
"The have a new manager and Glenn Fergusoin is a legend in the game - they just haven't had the luck recently.
"They will be desperate to get on track so we need to work hard and keep doing the simple things right."
Saturday 19 November - 1500 GMT
Ballymena Utd v Cliftonville
Crusaders v Lisburn Distillery
Donegal Celtic v Linfield
Dungannon Swifts v Portadown
Glentoran v Glenavon