Linfield striker Rory Patterson could be out of action until the New Year with his fractured wrist.
The former Coleraine forward had a follow-up x-ray on the injury on Thursday and was told that the wrist would be in plaster for four weeks.
The league leaders play Carrick Rangers at Seaview on Saturday.
Third-placed Cliftonville, who have won their last 10 games, have Aaron Smyth back from suspension for the match of the day against Glentoran.
Portadown, who lie second in the Premiership table, will be without the suspended Ross Redman for their trip to Lisburn Distillery, who have David Cushley serving a one-match ban.
Ballymena United welcome back defender Davy Munster for their home game against Donegal Celtic.
Glenavon face a crucial basement clash at home to fellow strugglers Dungannon Swifts, who are without Ryan O'Neill.
Crusaders pair Stuart Dallas (thigh) and Chris Morrow (ribs) return to the squad after injury for the visit to Ballycastle Road to take on Coleraine.
Carling Premiership fixtures - Saturday 26 November - 1500 GMT
Ballymena United v Donegal Celtic
Carrick Rangers v Linfield
Cliftonville v Glentoran
Coleraine v Crusaders
Glenavon v Dungannon Swifts
Lisburn Distillery v Portadown