Southport battled back from a goal behind to struggling Alfreton and maintain their surprise promotion bid.
After home keeper Tony McMillan had brilliantly saved Nathan Arnold's effort, Adam Quinn headed the Reds into the lead from Josh Low's cross.
The Sandgrounders turned the game when Kurtis Guthrie levelled with a deflected effort and Tony Gray slotted in from 12 yards.
Quinn almost pinched a point but he headed Low's corner wide.
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Southport boss Liam Watson told BBC Radio Merseyside:
"We've given a goal away from a set-play, which is very unlike us and we just needed a break.
"It was a great response, as we've lost a home game to Forest Green and then we've come from 1-0 down to Alfreton and this is a great three points for us.
"Hopefully we can go into the Wrexham game, which will be difficult with them beating Brentford in the FA Cup, but we'll try and get our ninth away win on the bounce."
Alfreton Town manager Nicky Law told BBC Radio Derby:
"When you look at the last four or five games, nothing has changed. If you're telling me they're a top three team and we're a bottom two team when there's no difference, I can't see it. I think we're every bit as good as them and that's not me being a bitter manager or anything.
"If you look at the teams today, Tony Gray's had one chance and he put it away, Guthrie the same. We came in first half and should've been 3-0 up and game over, but we're not clinical enough in front of goal.
"We had ample chances to win that game and we haven't done it and then down the other end, we make two errors in a minute and we get punished for them both."