Manchester City spent more than any other Premier League side on agents' fees over the past year with £9.66m going to player representatives.
Tottenham spent the second-highest amount, committing £7.57m to agents with Liverpool third on £7m.
Champions Manchester United spent £4.46m, the seventh-highest amount.
The £71.87m total spent by the clubs between 1 October 2010 and 30 September is the highest since the Premier League first published the figures in 2008.
It is a rise of £4.73m on the £67.14m spent between over the previous 12 months.
City, who lead the Premier League by five points, have invested heavily to bring in a series a high-profile players since Sheikh Mansour took over the club in September 2008.
Over the most recent accounting period, Atletico Madrid's Sergio Aguero arrived for a reported transfer fee of £38m and Wolsburg's Edin Dzeko and Arsenal's Samir Nasri also signed in big-money moves.
The three lowest spenders included two promoted sides in Swansea (£248,000) and Norwich (£710,000), with Wigan having spent £659,000.
Blackpool, who stayed within strict financial constraints during their unsuccessful fight against relegation from the Premier League last season, spent just £45,000 on agent fees between October 2009 and September 2010.
Total money spent on agents (Oct 2010 - Sep 2011):
Arsenal - £4,648,532.17
Aston Villa - £3,163,320.00
Blackburn Rovers - £4,227,056.93
Bolton Wanderers - £1,941,896.08
Chelsea - £6,457,747.37
Everton - £2,931,127.10
Fulham - £951,245.50
Liverpool - £7,000,242.99
Manchester City - £9,663,700.00
Manchester United - £4,457,103.00
Newcastle United - £6,380,488.00
Norwich City - £710,251.75
Queens Park Rangers - £2,499,214.00
Stoke City - £2,207,698.11
Sunderland - £3,735,384.29
Swansea City - £248,633.00
Tottenham Hotspur - £7,571,815.27
West Bromwich Albion - £1,305,576.38
Wigan Athletic - £659,800.00
Wolverhampton Wanderers - £1,107,918.00