Tottenham manager Harry Redknapp says he expects his team to be eliminated from the Europa League after their final group game in two weeks' time.
Spurs lost 2-1 at home to PAOK Salonika of Greece on Wednesday night and now need other results to go in their favour to make the knock-out stages.
"I am disappointed now because we are not going to be in the last 32," Redknapp said.
"I wanted to stay in the competition but it wasn't to be."
He added: "It's very slim - it is very difficult now. Full credit to the opposition, they worked hard and looked dangerous."
Redknapp made nine changes from the team that beat West Brom at the weekend, with Aaron Lennon and Jermain Defoe the only players keeping their places.
Scott Parker, Gareth Bale and Emmanuel Adebayor were all rested ahead of Saturday's Premier League game against Bolton as Spurs conceded two early goals and failed to recover despite their opponents defending a one-goal lead for the entire second half with 10 men.
Luka Modric scored Tottenham's goal from a penalty after Kostas Stafylidis was sent off for handling on the line.
Kazan and already-qualified PAOK need only to draw with each other in their final group game to ensure both teams make the last 32 at the expense of Spurs, who must beat Shamrock Rovers to stand a chance of progressing.
Tottenham took seven points from their opening three games in Group A but have lost to Kazan and PAOK in their last two outings in the competition.
PAOK manager Laszlo Boloni assured Redknapp he would not rest his starters against Rubin.
"I promise to Tottenham that I will not pick my second team," he said. "You know why? Because I don't have a second team."