Preston North End chairman Maurice Lindsay has resigned from his position for health reasons.
Lindsay had only recently returned to work after suffering from septicaemia following a knee operation in August.
The 70-year-old, a former director of Wigan Athletic and ex-chairman of Wigan rugby league club, took up his post at Deepdale in June 2010.
"I need time to rebuild my health," said Lindsay. "To be honest, it has been a difficult time."
Lindsay was appointed following Trevor Hemmings' takeover of Preston and was involved in the decision to sack manager Darren Ferguson last December.
He leaves Deepdale with North End 14th in League One.
"I have spent much of the last three months in hospital," added Lindsay on Preston's official website.
"Preston is still within striking distance of a promotion challenge and is even closer to the prospect of a Wembley appearance in the Johnstone's Paint Trophy.
"I wish them the best of luck and they will have my full support."
Preston have made no announcement as to who will take over from Lindsay.