Tranmere defender David Buchanan says injuries to key players have hindered their progress in recent weeks.
Owain Fon Williams, Ian Goodison, John Welsh, David Raven and Enoch Showunmi have all missed games as Rovers have fallen to 15th in League One.
"They're important and regular players and have played here over a number of years," he told BBC Radio Merseyside.
"They're in the starting line-up when fit and it does affect you when they are missing."
Buchanan added: "That's why it's important you have a decent squad, which we've got.
"But come Brentford on Saturday we'll have a few more players back and hopefully we can start better than we did against Sheffield Wednesday. I'm sure we'll get a positive result if we do."