Damon Gray's injury-time equaliser earned Berwick a point at 10-man Clyde.
The Bully Wee got off to a flying start when Gavin Brown found the top corner after six minutes following good work by John Sweeney.
The hosts doubled their advantage five minutes later, John Neill on hand to fire home a Jack Sloss cross.
Berwick pulled a goal back on the half-hour mark when Richard Walker headed Stuart Noble's cross home from close range.
Ian Gray was sent off just before the interval for his challenge on Damon Gray.
And it was Damon Gray who came back to haunt the home side when he popped up in the final minute of injury time to slot Noble's pass into the bottom corner.
Clyde: Crawford, Brown (Scullion 65), Oliver, McQueen, Sharp, Neill, Gray, Sweeney, Sloss, Brannan (Marr 90), McDonald (Ryan Kane 81).
Subs Not Used: McCue, Irvine.
Sent Off: Gray (45).
Booked: Oliver, Sweeney.
Goals: Brown 6, Neill 13.
Berwick: Barclay, McLean, Townsley, McLeod, Thompson (Deland 67), Walker, Currie, Greenhill (Ross Gray 80), McLaren (Gribben 67), Noble, Damon Gray.
Subs Not Used: Sorley, Ferguson.
Goals: Walker 29, Damon Gray 90.
Ref: Greg Aitken