Liverpool forward Fabio Borini needs surgery on his broken foot and is set to be out for around three months.
The 21-year-old, who joined from Roma in July, aggravated the injury while training with the Italian Under-21 squad for their fixture against Sweden last week.
A club statement said: "Typically, an injury of this nature requires a three-month rehabilitation period."
Liverpool now have only Luis Suarez available as a recognised striker.
Borini, a former Chelsea trainee, moved to Anfield in the summer for an undisclosed fee reported to be in the region of £11m.
He scored on his home debut in August in a 3-0 win in Europa League qualifying against FC Gomel, but has yet to find the net again.
Liverpool loaned Andy Carroll to West Ham on transfer deadline day, leaving only Suarez and youngsters Daniel Pacheco, Samed Yesil, Jerome Sinclair and Adam Morgan as possible striking options.
It is understood Liverpool have the option to recall Carroll from West Ham in January.