Angola striker Manucho scored the opener in the ninth minute for Real Valladolid away to Malaga but his early jubilation was spoiled when he was sent off on 81 minutes - and his side lost 2-1.
Morocco striker Youssef El-Arabi pulled a goal back for 10-man Granada but his side still went down 2-1 at home to Real Zaragoza.
Ivory Coast striker Wilfried Bony became top scorer in the Dutch top-flight at the weekend after his two goals for Vitesse Arnhem helped his side to secure all three points in the 3-0 win over NAC Breda.
Zambia striker Jacob Mulenga secured the points for Utrecht with his 40th-minute goal as his side came from behind to beat ADO Den Haag 2-1.
League holders Montpellier continue to struggle after losing 2-1 to Rennes. Morocco midfielder Younes Belhanda scored in the 69th minute from the penalty spot for Montpellier. Cameroon midfielder Jean Makoun had given Rennes a 13th-minute lead.
Vincent Aboubakar scored twice in the last 10 minutes for Valenciennes who crushed Lorient 6-1. The Cameroon striker had only been on the pitch as a substitute for two minutes when he scored his first goal of the season in the 81st minute before helping to finish the rout in the last minute.
Karim Matmour gave Eintracht Frankfurt the lead in the fifth minute as they strolled to a 3-1 win over Hannover '96. It was the Algeria midfielder's first goal in the Bundesliga this season.
Nigeria striker Issy Lucky Idaho scored the vita third goal for Zorya who picked up all three points by beating Dnipro Dnipropetrovsk 3-2.
The Greek league's top scorer Rafik Djebbour from Algeria took his tally to eight goals after scoring twice at the weekend for Olympiakos who dismissed Xanthi 4-0.
Anzhi Makhachkala maintained their lead at the top of the table after coming from behind to beat Spartak Moscow 2-1. Anzhi equalised through their Ivory Coast striker Lacina Traore who came on as a second-half substitute to level in the 64th minute.
Nigeria's Ahmed Musa continued his fine form after scoring his fifth goal of the season for CSKA Moscow in their 2-0 win over Rubin Kazan.
Ebrahima Ibou Sawaneh became the top scorer in the league after his hat-trick inspired Leuven from a goal down to a 4-1 win over Club Bruges. The Gambia striker, who has 11 goals this season, scored twice in the first half and completing his hat-trick in the 78th minute from the penalty spot. Leuven's fourth goal came through their Zimbabwe midfielder Ovidy Karuru.
Morocco midfielder Moustapha Oussala scored the only goal of the game as his side Kortrijk edged out Gent to move to fourth position in the standings.
Lokeren won 3-0 away at Zulte-Waregem with the Tunisia striker Hamdi Harbaoui scoring the third goal in the 81st minute.
Mechelen played the last three minutes with 10 men after the Cameroon defender Antonio Ghomsi was sent-off, but they still beat Cercle Bruges 2-1 with Ghana midfielder Abdul-Yakinu Iddi scoring the opening goal.
Cameroon striker Aloys Nong scored twice in the last two minutes for Mons who came from behind to beat Standard Liege 3-1. Gambia striker Mustapha Jarju had equalised for Mons in the 34th minute.
There were plenty of African goal scorers in the game between Antalyaspor and Sivasspor. Nigeria's Isaac Promise scored twice, while two other goals by Senegal striker Lamine Diatta and Morocco midfielder Ismail Aissati gave Antalya a 4-2 victory. Sivasspor's Nigeria striker Michael Eneramo scored one of the goals for his side in the 48th minute.
Senegal striker Moussa Sow equalised for Fenerbahce in the 23rd minute in his side's 1-1 draw with Bursaspor.
Another Senegalese, Diomansy Kamara, scored twice for Eskisehirspor who outclassed Karabukspor 5-2.
Malian Modibo Maiga was on target for West Ham, helping his side to beat their fellow Premier League newcomers 4-1. Maiga, whose two other goals since his pre-season transfer came in the League Cup, had only been on the pitch five minutes when he beat three Southampton defenders with a fine run before curling his shot past Artur Boruc.
There was misery for two of Newcastle's Africans involved in the 1-1 draw at Sunderland and Newcastle. Ivory Coast Coast midfielder Cheick Tiote was sent off mid-way through the first half for crunching into Steven Fletcher with his foot high. Senegal striker Demba Ba scored an own goal late on, deflected John O'Shea's header into his own net, to hand Sunderland a share of the points.
Everton's South African midfielder Steven Pienaar was another to see red. The former Bafana Bafana captain was dismissed for two bookings in the second half of a 1-1 draw at QPR. Pienaar 's second booking was for a trip on Jose Bosingwa - a decision which Everton boss David Moyes called "ludicrous".
Kenyan striker Victor Mugabe Wanyama scored twice in the space of six minutes to help Celtic beat St Mirren 5-0. Nigeria defender Efe Ambrose also scored in the game as Celtic led 4-0 at half-time.