Tom's Elliott's eighth goal of the season helped Cambridge end their run of five matches without a win with victory over Macclesfield.
After a drab first half, the U's took the lead when Robbie Willmott collected a long clearance to fire home.
Soon after, Elliott powered in a header from a pin-point James Jennings delivery to double their advantage.
The Silkmen were restricted to long-range efforts, with Matthew Barnes-Homer coming closest to a goal.
Defeat for the visitors ends their run of four consecutive wins in all competitions, and leaves them five points off the Blue Square Bet Premier play-off places.
Meanwhile Cambridge find themselves two points off the relegation zone in 18th place.
The U's handed a debut to loan signing Jed Steer after Jonathan Hedge conceded six in their last game, a 6-2 defeat by Newport.
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Cambridge United head coach Richard Money told BBC Radio Cambridgeshire:
"That was a proper team, a proper performance. People want to know if we are going in the right direction and how we want to play and and probably for the first time that's getting somewhere close to it.
"I wouldn't want anyone to think we've made the goalkeeper a scapegoat for what happened on Tuesday because that is not the case but something needed to be done.
"The relationship between the back-line and the midfield-line and the guy behind just hasn't been right. We just felt we needed somebody new."