Interim Scotland manager Billy Stark has made few changes in his squad for the friendly with Luxembourg.
Aston Villa's Barry Bannan is recalled while Steven Whittaker and Phil Bardsley return from injury.
However, Gary Caldwell, Scott Brown, Alan Hutton and Allan McGregor are missing, with Stark insisting he was keen to rest some senior players.
"I've spoken to them and they're grateful to have the opportunity to have a break from this game," he said.
"For a November friendly, a lot of football has already been played and some players will have niggles they would love the opportunity to shake off.
"Allan McGregor and Gary Caldwell, in particular, have been real stalwarts and terrific players for the national team in recent years.
"There is nothing more to it than that. It's simply the stage they are at. Allan McGregor rushed back from injury and was an absolute star for us in those games.
"But he's out in Turkey now and, with family circumstances, it was a good opportunity to show a bit of compassion in that sense."
Kilmarnock's Cammy Bell joins regular squad goalkeepers Matt Gilks and David Marshall in Stark's pool while there are also places for Blackburn defender Grant Hanley and Everton forward Steven Naismith, who missed Scotland's last two matches because of suspension.
Stark has been put in caretaker charge of the national team following Donald Park, the Scottish Football Association's head of coach education, will assist Stark in Wednesday's match at the Stade Josy Barthel.
Scotland squad to face Luxembourg
Goalkeepers: Cameron Bell (Kilmarnock), Matt Gilks (Blackpool), David Marshall (Cardiff City)
Defenders: Phil Bardsley (Sunderland), Christophe Berra (Wolverhampton Wanderers), Grant Hanley (Blackburn Rovers), Charlie Mulgrew (Celtic), Andy Webster (Heart of Midlothian), Steven Whittaker (Norwich City)
Midfielders: Charlie Adam (Stoke City), Barry Bannan (Aston Villa), Kris Commons (Celtic), Darren Fletcher (Manchester United), Shaun Maloney (Wigan Athletic), James Morrison (West Bromwich Albion), Matt Phillips (Blackpool)
Forwards: Steven Fletcher (Sunderland), Jamie Mackie (Queens Park Rangers), Kenny Miller (Vancouver Whitecaps), Steven Naismith (Everton), Jordan Rhodes (Blackburn Rovers)