Middlesbrough boss Tony Mowbray says the potential for injuries to players on international duty is "part and parcel" for any successful club.
On-loan Chelsea midfielder Josh McEachran picked up an ankle injury with England Under-21s on Tuesday.
Mowbray told BBC Look North: "It's a concern but I'd never deprive players from playing for their country.
"I'm delighted when we get call-ups but there is always a fear of players coming back unfit."
He added: "Every manager wants a total week of preparing your team for the next game, possession work, and yet when players are away you don't get them on the training ground.
"But that's part and parcel of having a decent team with players good enough to play at international level."
McEachran returned to Middlesbrough on Wednesday night, and was supervised by the club's medical staff with a view to his selection for Saturday's Championship trip to Cardiff City.
"It's disappointing when a player like Josh, who has been so influential, picks up an injury away on international duty," Mowbray added.
"We haven't ruled him out yet. He didn't train today but he was out on the grass with the physio testing it out and we'll give him every chance.
"If he can come through training tomorrow then he'll travel with us. But if it's too sore we won't risk him as we've got a lot of games coming."