Leyton Orient and Crewe shared the points after the Alex's Byron Moore cancelled out Lee Cook's opener.
David Mooney struck the crossbar for Orient and new signing Charlie MacDonald saw his volley hit the post.
Cook opened the scoring after keeper Steve Phillips could only palm a Dean Cox cross into the path of the winger.
But, against the run of play, the visitors equalised when Moore ran in unmarked to meet a left-wing cross from Luke Murphy and head home.
VIEW FROM THE DRESSING ROOM
Leyton Orient manager Russell Slade told BBC London 94.9:
"We should have been four or five one up in the first period.
"I thought we were absolutely excellent.
"The game should have been out of sight by half time. They should have been dead and buried."