Mark Duffy's goal was enough to seal victory for Scunthorpe over Stevenage and put them three points clear of the League One relegation zone.
The midfielder cut in from the right-hand side after receiving the ball from Karl Hawley, before finding the far corner from the edge of the area.
Before the breakthrough, Hawley had seen his powerful header hit the bar.
Boro offered little going forward and failed to find an equaliser, falling to their fifth successive defeat.
VIEW FROM THE DRESSING ROOM
Scunthorpe boss Brian Laws told BBC Radio Humberside:
"Patience, belief, bravery, I think those elements contributed to our win today.
"Particularly after Saturday's performance, and how the game panned out, as in the way we got sucked into a fight, and I said if we get sucked in again against a big side in Stevenage we'll have the same issues and problems
"I think that's probably the best 90 minutes that we've shown in most of the games, in any of the games the most complete performance."