Jacques Maghoma's brace saw Burton defeat Wycombe to move into the League Two automatic promotion places.
The Brewers, who were thrashed 7-1 by Port Vale last week, went ahead shortly after the break when Maghoma capitalised on a mistake by Chairboys defender Michael Harriman to fire home.
Maghoma's second came when picked up a stray Harriman pass to score.
Wycombe struggled throughout, coming closest when Gareth Ainsworth's volley was saved by home keeper Dean Lyness.
Burton are now two points clear of fourth-placed Northampton, who have a game in hand.
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Burton Albion manager Gary Rowett told BBC Radio Derby:
"That might just be the win that gets us enough points to minimum get us into the play-offs.
"Tonight was almost the pivotal moment of our season. Had we lost again, we could have seen our season just slip away a little bit.
"I've been warmed by the whole performance. It was a magnificent performance in light of the fact we could have been very, very nervy. And who would have forgiven us after the absolute drubbing we took at Port Vale?"