Woking's five goals in the first half were enough to stave off a sensational second-half comeback from Macclesfield.
The hosts found themselves 2-0 ahead after seven minutes through Billy Knott and Kevin Betsy.
Jayden Stockley netted a penalty, awarded for Jack Mackreth's foul on Knott, and added a second before Knott also grabbed another to make it 5-0.
But a spirited Macc hit back - Waide Fairhurst scored twice, while Guy Madjo and Arthur Gnahoua also found the net.
VIEW FROM DRESSING ROOM
Woking manager Garry Hill told BBC Surrey:
"I think we played some very good football first half and when you're 5-0 up at half-time the game should be over.
"It's very frustrating as a manager and when you watch that, they get a goal which didn't affect us but all of sudden we deteriorated quickly.
"We didn't work second half and there's no excuses. I'm very disappointed."