Manchester United goalkeeper David De Gea has been included in an experienced Spain squad for June's European Under-21 Championship in Israel.
The 22-year-old is one of five players named in the 23 who helped Spain lift the trophy in 2011 in Denmark.
Full internationals Thiago Alcantara, Isco and Iker Muniain will travel rather than take part in the senior team's Confederations Cup campaign.
Wigan loanee goalkeeper Joel Robles, 22, has also been been selected.
De Gea, who became the world's second most expensive goalkeeper when he signed for Manchester United from Atletico Madrid in June 2011 for £18.9m, has 22 caps for the Under-21 team.
Barcelona's Martin Montoya and Villarreal's Diego Marino join De Gea, Alcantara and Muniain in the squad as players who took part in the 2011 triumph.
Spain coach Julen Lopetegui believes his side - who begin their title defence against Russia before facing Germany and Holland in Group B - have a tough task ahead to retain their trophy.
They qualified for the finals, which take place in Jerusalem, Tel Aviv, Netanya and Petah Tikva, with a near-perfect record of nine wins and a draw and will travel to their base camp in Israel on 3 June, three days before their opening game.
Lopetegui said: "This tournament is a very attractive one and contains some really big names. The feelings are very positive.
"The three national teams we will face in the group stage are all very competitive and contain players with a lot of experience who have featured for their seniors. We have a wonderful challenge ahead of us."
Goalkeepers: David De Gea (Manchester United), Diego Marino (Villarreal), Joel Robles (Atletico Madrid).
Defenders: Marc Bartra (Barcelona), Dani Carvajal (Bayer Leverkusen), Nacho Fernandez (Real Madrid), Alvaro (Real Zaragoza), Inigo Martínez (Real Sociedad), Marc Muniesa (Barcelona), Martín Montoya (Barcelona), Alberto Moreno (Sevilla).
Midfielders: Thiago Alcantara (Barcelona), Ignacio Camacho (Malaga), Sergio Canales (Valencia), Asier Illarramendi (Real Sociedad), Isco (Malaga), Koke (Atletico Madrid), Pablo Sarabia (Getafe).
Forwards: Alvaro Morata (Real Madrid), Rodrigo (Benfica), Iker Muniain (Athletic Bilbao), Cristian Tello (Barcelona), Alvaro Vazquez (Getafe).