Chelsea pair Fernando Torres and Juan Mata have been left out of the Spain squad for next week's World Cup qualifier against Finland and a friendly with Chile.
Torres, 29, and 25-year-old Mata both started the
But both players have started just one league game out of three under Chelsea boss Jose Mourinho this season.
Coach Vicente Del Bosque said: "I have chosen those who are in the best form."
Chelsea right-back Cesar Azpilicueta has also been left out.
Spain are top of World Cup qualifying Group I after five games but were held to
Del Bosque's side play Finland in Helsinki on Friday 6 September and meet Chile in Geneva four days later.
Arsenal duo Nacho Monreal and Santi Cazorla are included, as are Tottenham forward Roberto Soldado and Manchester City trio Alvaro Negredo, David Silva and Jesus Navas.
Goalkeepers: Iker Casillas (Real Madrid), Victor Valdes (Barcelona), Pepe Reina (Napoli)
Defenders: Alvaro Arbeloa (Real Madrid), Sergio Ramos (Real Madrid), Jordi Alba (Barcelona), Raul Albiol (Napoli), Inigo Martinez (Real Sociedad), Nacho Monreal (Arsenal)
Midfielders: Andres Iniesta (Barcelona), Santi Cazorla (Arsenal), Isco (Real Madrid), Koke (Atletico Madrid), Xavi (Barcelona), Mario Suarez (Atletico Madrid), Sergio Busquets (Barcelona)
Forwards: Jesus Navas (Manchester City), David Silva (Manchester City), Alvaro Negredo (Manchester City), Roberto Soldado (Tottenham Hotspur), Cesc Fabregas (Barcelona), Pedro (Barcelona), David Villa (Atletico Madrid)