Morecambe will be without centre-back Chris McCready for three months because of a fractured collarbone.
The 32-year-old was hurt in a tangle with Plymouth striker Marvin Morgan during the first half of at the Globe Arena.
"He fell awkwardly and snapped his collarbone," Shrimps manager Jim Bentley told BBC Radio Lancashire.
"I feel sorry for him because he's a fantastic pro. These things happen. We'll have to get on with it."